By lending them a gene normally reserved for other classes of animals, researchers have shown they can rescue flies from their Parkinson’s like symptoms,
70% Off 2014 Nike Air Yeezy For Sale Free Shipping With Fast Delivery, including movement defects and excess free radicals produced in power generating cellular components called mitochondria. The gene swap also protects healthy flies’ mitochondria, and to a large extent the flies themselves, from the damaging effects of cyanide and other toxins,
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The key gene (single subunit alternative oxidase or AOX) in essence acts as a bypass for blockages in the so called oxidative phosphorylation (OXPHOS) cytochrome chain in mitochondria. Howard Jacobs, who led the study at the University of Tampere in Finland,
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"This is the first whole organism test for the idea that you can take a gene that encodes a single polypeptide and bypass OXPHOS where it is blocked," said Jacobs, emphasizing that OXPHOS includes dozens of components and hundreds of proteins. "You may lose power from one [molecular] ‘turbine,’ but power from the others can be restored. With a single peptide, you can bypass two thirds of the system. That’s the beauty of the idea."

Defects in mitochondrial OXPHOS are associated with diverse and mostly intractable human disorders, the researchers said. Therefore, there’s a chance that the strategy might also prove beneficial in mammals, including humans,
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On the other hand, most plants,
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In a previous study, Jacobs and his colleagues tested the idea that AOX might bypass the consequences of OXPHOS inhibition in human cells. They introduced the gene into human cells by inserting DNA taken from the urochordate Ciona intestinalis. Those studies found that the protein encoded by the Ciona AOX gene made its way to mitochondria,
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Now,
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The findings led the researchers to conclude that "AOX appears to offer promise as a wide spectrum therapeutic tool in OXPHOS disorders." The next step is to test whether the findings in flies will also hold true in mammals,
Where Can i Buy Womens Nike Air Yeezy Red October Come On And Join Us, Jacobs said. His hope is that the AOX gene might someday be delivered to humans via a suitable gene therapy, although he admits that goal assumes many things will fall into place.

"OXPHOS dysfunction is not just a problem in some rare genetic disorders or in degenerative diseases,
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So, why don’t we have this gene in the first place, one might ask?

Jacobs said he isn’t entirely sure, but he suspects the gene renders energy production by mitochondria less efficient under normal circumstances,
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